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. 2020 Aug 28;8:e9812. doi: 10.7717/peerj.9812

Table 3. LC-MS/MS detected steroids that varied in GCs of DOR with significant difference.

Components Formula m/z FC p-value Class Sub class label
Hydroxyprogesterone C21H30O3 330.2190 0.0404 0.0381 Steroids and steroid derivatives Pregnane steroids down
Progesterone C21H30O2 314.2244 0.0785 0.0025 Steroids and steroid derivatives Pregnane steroids down
3 alpha-hydroxydesogestrel C22H30O2 326.2241 0.0657 0.0027 Steroids and steroid derivatives Estrane steroids down
(6beta,8xi,11beta,14xi,16alpha)-9-fluoro-6,11,17,21-tetrahydroxy-16-methylpregna-1,4-diene-3,20-dione C22H29FO6 408.1960 0.0290 0.0093 Steroids and steroid derivatives Hydroxysteroids down
(6beta,8xi,11beta,14xi,16alpha)-9-fluoro-6,11,17,21-tetrahydroxy-16-methylpregna-1,4-diene-3,20-dione C22H29FO6 408.1959 0.0340 0.0179 Steroids and steroid derivatives Hydroxysteroids down
4,6-cholestadien-3-one C27H42O 382.3229 0.0343 0.0352 Steroids and steroid derivatives Cholestane steroids down
Cholest-4-en-3-one C27H44O 384.3385 0.0796 0.0273 Steroids and steroid derivatives Cholestane steroids down

Notes.

LC-MS/MS
liquid chromatography-tandem mass spectrometry
GCs
granulosa cells
DOR
diminished ovarian reserve
FC
fold change