Table 3. LC-MS/MS detected steroids that varied in GCs of DOR with significant difference.
Components | Formula | m/z | FC | p-value | Class | Sub class | label |
---|---|---|---|---|---|---|---|
Hydroxyprogesterone | C21H30O3 | 330.2190 | 0.0404 | 0.0381 | Steroids and steroid derivatives | Pregnane steroids | down |
Progesterone | C21H30O2 | 314.2244 | 0.0785 | 0.0025 | Steroids and steroid derivatives | Pregnane steroids | down |
3 alpha-hydroxydesogestrel | C22H30O2 | 326.2241 | 0.0657 | 0.0027 | Steroids and steroid derivatives | Estrane steroids | down |
(6beta,8xi,11beta,14xi,16alpha)-9-fluoro-6,11,17,21-tetrahydroxy-16-methylpregna-1,4-diene-3,20-dione | C22H29FO6 | 408.1960 | 0.0290 | 0.0093 | Steroids and steroid derivatives | Hydroxysteroids | down |
(6beta,8xi,11beta,14xi,16alpha)-9-fluoro-6,11,17,21-tetrahydroxy-16-methylpregna-1,4-diene-3,20-dione | C22H29FO6 | 408.1959 | 0.0340 | 0.0179 | Steroids and steroid derivatives | Hydroxysteroids | down |
4,6-cholestadien-3-one | C27H42O | 382.3229 | 0.0343 | 0.0352 | Steroids and steroid derivatives | Cholestane steroids | down |
Cholest-4-en-3-one | C27H44O | 384.3385 | 0.0796 | 0.0273 | Steroids and steroid derivatives | Cholestane steroids | down |
Notes.
- LC-MS/MS
- liquid chromatography-tandem mass spectrometry
- GCs
- granulosa cells
- DOR
- diminished ovarian reserve
- FC
- fold change