Table 1.
Antiviral activity of flex-analogues against various flaviviruses including Dengue (DENV), Zika (ZIKV), and Yellow Fever Virus (YFV) in Vero76 cells.
| Compound | DENV |
ZIKV |
YFV |
|||
|---|---|---|---|---|---|---|
| aEC50 | bCC50 | EC50 | CC50 | EC50 | CC50 | |
| 1 | 0.057 | 1.20 | >1.80 | >1.80 | 0.37 | 1.7 |
| 1-Ac | 6.1 | 65 | >100 | >100 | >57 | 57 |
| 1-MG | >57 | 57 | >31 | 31 | >55 | 55 |
| 2 | >50 | 50 | >76 | 76 | >58 | 58 |
| 2-Ac | 19 | 53 | 79 | >100 | >58 | 58 |
| 2-MG | >53 | 53 | >56 | 56 | >53 | 53 |
Values are reported in µM.
a
EC50: effective concentration showing 50% inhibition of virus-induced CPE.
b
CC50: cytotoxic concentration showing 50% inhibition of cell survival.