Table 2.

Inhibition of MTase activity of compounds 1-TP and 2-TP against DENV NS5-MTase, ZIKV NS5-MTase, and human N7 MTase.

Compound	ZIKV MTase IC50	DENV MTase IC50	hN7 MTase IC50
1-TP	1.7 µM	8.4 µM	49 µM
2-TP	0.15 µM	1.1 µM	13 µM