Figure 2.

C-peptide and C-peptide/glucose. Serum C-peptide (A and B) and C-peptide/glucose (E and F) vs. time during the 2-h two-step glucose clamp in 10 HNF1A mutation carriers and 10 control subjects without diabetes. Corresponding bsAUC_{0–60 min} and bsAUC_{60–120 min} are presented in C, D, G, and H. Continuous infusions of saline (NaCl), GIP, or GLP-1 were started at time 0 min preceded by either single-dose SU 1 mg glimepiride or placebo (PLA) at time −90 min. Data from time 120 min to 125 min is magnified in insets in A, B, E, and F. Data are presented as mean ± SEM. Symbols show significant differences (P < 0.05) between interventions: *significantly greater than PLA+NaCl; †significantly greater than SU+NaCl; ‡significantly greater than PLA+GIP; §significantly greater than PLA+GLP-1; ‖significantly greater than SU+GIP.