Figure 4.

Interaction between SU and the incretin hormones. bsAUC_{0–120 min} for C-peptide and C-peptide/glucose for 10 HNF1A mutation carriers and 10 control subjects without diabetes during the 2-h two-step glucose clamp. Continuous infusions of saline (NaCl), GIP, or GLP-1 were started at time 0 min preceded by either single-dose SU 1 mg glimepiride or placebo (PLA) at time −90 min. Data are shown as mean percentage ± SEM. A: The reference value (100%) is the sum of bsAUC_{0–120 min, SU+NaCl} + bsAUC_{0–120 min, PLA+GIP}, which on the graphs is shown as SU+GIP (additive). SU+GIP (observed) is the observed bsAUC_{0–120 min, SU+GIP} during our study. If SU+GIP (observed) is greater than SU+GIP (additive), this is indicative of an interaction and thus a supra-additive effect. B: The calculations are identical for A, but with GLP-1 instead of GIP.