Table 2.
Overview of HNF1A mutations, treatment, and diabetes status
| Subject | Mutation chromosome 12 | Treatment | Diabetes status |
|---|---|---|---|
| HNF1A-1 | Cys241Gly | Glimepiride | Diabetes |
| HNF1A-2 | IVSnt-2 a->g | Diet | No diabetes |
| HNF1A-3 | c.1623+1 g->t | Glimepiride + linagliptin | Diabetes |
| HNF1A-4 | Pro291fsinsC | Glimepiride + liraglutide | Diabetes |
| HNF1A-5 | Ala559fsinsA | Linagliptin | Diabetes |
| HNF1A-6 | Deletion (exon2–10) | Glimepiride | Diabetes |
| HNF1A-7 | Pro291fsinsC | Repaglinide + metformin | Diabetes |
| HNF1A-8 | Pro291fsinsC | Glimepiride | Diabetes |
| HNF1A-9 | Pro379fsdelCT | Diet | No diabetes |
| HNF1A-10 | Glu234Term | Diet | Diabetes* |
“Diabetes” is defined as one measurement of HbA1c ≥48 mmol/mol at any time.
*
Patient diagnosed with gestational diabetes mellitus during two pregnancies verified with oral glucose tolerance tests.