Table 1.
Demographic Details, Clinical Characteristics, and Reverse-Transcriptase Polymerase Chain Reaction Results of Patients
| Patient No. | Age (yrs) | Gender | Severity | Systemic Symptoms | Duration (Days)∗ | Group 1 |
Group 2 |
Group 3 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Conjunctival Swab plus Schirmer’s Test Strips |
Conjunctival Swab |
Schirmer’s Test Strips |
|||||||||||||||
| Tear Results | Cyclic Threshold E Gene | Cyclic Threshold ORF1b | Cyclic Threshold RdRP | Tear Results | Cyclic Threshold E Gene | Cyclic Threshold ORF1b | Cyclic Threshold RdRP | Tear Results | Cyclic Threshold E Gene | Cyclic Threshold ORF1b | Cyclic Threshold RdRP | ||||||
| 1 | 73 | M | Moderate | Cough, fever, SOB, DM, HTN | 22 | Negative | Negative | Negative | |||||||||
| 2 | 78 | F | Moderate | Chest pain, cough, CAD, HTN, DM | 5 | Negative | Negative | Negative | |||||||||
| 3 | 68 | F | Severe | Fever, SOB, DM, AKI | 9 | Positive | 30 | 30 | ND | Negative | Negative | ||||||
| 4 | 78 | M | Severe | SOB, cough, COPD, HTN | 7 | Negative | Positive | 29 | 32 | ND | Negative | ||||||
| 5 | 63 | M | Moderate | Fever, sore throat, DM, HTN, CAD | 5 | Negative | Negative | Negative | |||||||||
| 5 | 60 | F | Moderate | Fever, cough, CLD | 6 | Negative | Negative | Negative | |||||||||
| 7 | 27 | M | Moderate | Fever, diarrhea | 8 | Negative | Negative | Negative | |||||||||
| 8 | 48 | F | Moderate | Sore throat | 5 | Negative | Negative | Negative | |||||||||
| 9 | 60 | F | Moderate | Chest pain, DM, HTN | 6 | Negative | Negative | Negative | |||||||||
| 10 | 60 | F | Moderate | Fever, headache, HTN, CKD | 5 | Negative | Negative | Negative | |||||||||
| 11 | 71 | M | Moderate | Generalized weakness, DM, HTN, CAD | 5 | Negative | Negative | Negative | |||||||||
| 12 | 32 | M | Severe | Cough, SOB, fever, asthma | 6 | Negative | Negative | Negative | |||||||||
| 13 | 67 | M | Severe | Cough, SOB, fever, DM, HTN, CAD | 7 | Negative | Negative | Negative | |||||||||
| 14 | 51 | F | Moderate | Diarrhea, vomiting, fever, HTN, depression | 7 | Negative | Negative | Negative | |||||||||
| 15 | 20 | M | Moderate | Fever, vomiting, acute viral hepatitis with pancreatitis | 5 | Negative | Negative | Negative | |||||||||
| 16 | 35 | f | Severe | DM, HTN, RHD (severe MS) | 4 | Negative | Negative | Negative | |||||||||
| 17 | 35 | F | Moderate | Fever, vomiting | 5 | Negative | Positive | 29 | 30 | ND | Negative | ||||||
| 18 | 66 | M | Moderate | Fever, vomiting, seizure disorder | 3 | Negative | Negative | Positive | 33 | 35 | ND | ||||||
| 19 | 30 | M | Severe | Cough, SOB | 5 | Negative | Negative | Negative | |||||||||
| 20 | 55 | M | Moderate | Fever, cough, SOB, DM, HT, active TB | 15 | Negative | Negative | Negative | |||||||||
| 21 | 44 | M | Moderate | Fever | 8 | Negative | Negative | Negative | |||||||||
| 22 | 18 | M | Moderate | Fever, vomiting, anemia, thrombocytopenia | 4 | Negative | Negative | Negative | |||||||||
| 23 | 61 | F | Severe | Fever, SOB, HTN | 5 | Negative | Negative | Negative | |||||||||
| 24 | 64 | M | Moderate | Cough, sore throat, DM, HTN, CAD | 8 | Negative | Negative | Negative | |||||||||
| 25 | 45 | M | Severe | SOB, body aches, dizziness, DM | 4 | Negative | Negative | Negative | |||||||||
| 26 | 60 | M | Severe | SOB, DM | 4 | Negative | Positive | 33 | 32 | ND | Negative | ||||||
| 27 | 66 | F | Severe | Cough, SOB, fever, DM, HTN | 7 | Negative | Negative | Negative | |||||||||
| 28 | 58 | M | Severe | Fever, cough, SOB, DM, HTN, CAD | 11 | Negative | Negative | Negative | |||||||||
| 29 | 73 | F | Severe | SOB, COPD | 4 | Negative | Negative | Negative | |||||||||
| 30 | 74 | M | Severe | SOB, fever, cough | 4 | Negative | Negative | Negative | |||||||||
| 31 | 62 | M | Severe | Fever, cough, SOB, DM | 8 | Positive | 22 | 22 | 23 | Positive | 23 | 23 | 22 | Positive | 28 | 27 | 27 |
| 32 | 21 | F | Severe | Cough | 5 | Negative | Negative | Negative | |||||||||
| 33 | 63 | M | Severe | SOB, fever, DM | 4 | Positive | 34 | 33 | ND | Negative | Negative | ||||||
| 34 | 23 | F | Moderate | SOB, fever, DM, HTN, COPD | 5 | Negative | Positive | 34 | ND | 32 | Negative | ||||||
| 35 | 60 | F | Severe | Cough, SOB, HTN, DM | 5 | Negative | Negative | Negative | |||||||||
| 36 | 52 | M | Moderate | Chest pain, HTN, CAD | 4 | Negative | Negative | Negative | |||||||||
| 37 | 68 | F | Severe | Fever, cough, CKD, DM, HTN | 8 | Positive | 25 | 26 | ND | Positive | 30 | 32 | ND | Positive | 35 | 35 | ND |
| 38 | 66 | M | Moderate | Cough, SOB, DM, HTN | 6 | Negative | Negative | Negative | |||||||||
| 39 | 80 | M | Moderate | SOB, MODS with AKI | 4 | Positive | 26 | 27 | ND | Positive | 29 | 28 | ND | Positive | 28 | 28 | ND |
| 40 | 55 | M | Moderate | Cough, fever, B-cell lymphoma | 5 | Positive | 14 | 16 | 18 | Positive | 15 | 16 | 18 | Positive | 15 | 16 | 18 |
| 41 | 33 | M | Severe | SOB, CKD | 4 | Positive | 32 | 32 | ND | Positive | 31 | 28 | ND | Positive | 26 | 27 | ND |
| 42 | 20 | M | Moderate | SOB, CKD | 4 | Negative | Negative | Negative | |||||||||
| 43 | 60 | F | Severe | Fever, cough, SOB, CKD | 5 | Negative | Negative | Negative | |||||||||
| 44 | 49 | F | Moderate | Fever, SOB | 5 | Positive | 34 | 34 | ND | Negative | Negative | ||||||
| 45 | 51 | F | Severe | Fever, SOB, vomiting, DM, CKD | 8 | Negative | Negative | Negative | |||||||||
| 46 | 34 | M | Moderate | Cough, sore throat, chest pain, DM, HTN, CAD | 4 | Negative | Negative | Negative | |||||||||
| 47 | 53 | F | Moderate | SOB, HTN, CKD | 8 | Negative | Negative | Negative | |||||||||
| 48 | 60 | F | Severe | SOB, cough, fever, asthma | 7 | Negative | Negative | Negative | |||||||||
| 49 | 47 | F | Severe | Diarrhea, HTN, CKD | 5 | Negative | Negative | Negative | |||||||||
| 50 | 78 | F | Moderate | Fever, DM, HTN, CAD | 7 | Negative | Negative | Negative | |||||||||
| 51 | 75 | F | Severe | Cough, SOB | 7 | Negative | Negative | Negative | |||||||||
| 52 | 58 | M | Severe | SOB, DM, CAD | 5 | Positive | 33 | 34 | ND | Negative | Negative | ||||||
| 53 | 40 | M | Moderate | Fever, SOB | 21 | Negative | Negative | Negative | |||||||||
| 54 | 73 | M | Severe | SOB, fever, smoker | 9 | Positive | 31 | 31 | ND | Negative | Negative | ||||||
| 55 | 62 | M | Moderate | SOB, Hodgkin`s lymphoma | 4 | Negative | Negative | Negative | |||||||||
| 56 | 44 | M | Severe | cough, SOB, DM | 6 | Negative | Negative | Negative | |||||||||
| 57 | 81 | F | Moderate | Fever, cough, SOB, DM, HTN, CAD | 14 | Negative | Negative | Negative | |||||||||
| 58 | 63 | F | Moderate | Fever, SOB, cough, DM, HTN | 8 | Negative | Negative | Negative | |||||||||
| 59 | 48 | M | Moderate | Cough, HTN, CKD | 3 | Negative | rejected | Negative | |||||||||
| 60 | 50 | F | Severe | Sore throat, fever, SOB | 5 | Negative | Negative | Negative | |||||||||
| 61 | 73 | F | Severe | Cough, SOB, HTN, CKD | 4 | Negative | Negative | Negative | |||||||||
| 62 | 57 | M | Moderate | Fever, HBs Ag positive | 4 | Negative | Negative | Negative | |||||||||
| 63 | 56 | M | Severe | Fever, cough, SOB, B/L pneumonitis | 11 | Negative | Negative | Negative | |||||||||
| 64 | 47 | M | Severe | SOB, cough, fever, CKD | 9 | Negative | Negative | Negative | |||||||||
| 65 | 60 | F | Severe | Cough, SOB, fever, COPD | 7 | Negative | rejected | Negative | |||||||||
| 66 | 48 | M | Severe | Fever, cough, SOB, DM, HTN, AKI | 8 | Negative | Negative | Negative | |||||||||
| 67 | 60 | M | Moderate | Fever, sore throat, cough, DM, HTN | 8 | Negative | Negative | Negative | |||||||||
| 68 | 62 | F | Severe | Fever, cough, SOB, HTN | 7 | Negative | Negative | Negative | |||||||||
| 69 | 80 | F | Severe | Fever, cough, SOB | 18 | Negative | Positive | 32 | 33 | ND | Negative | ||||||
| 70 | 62 | F | Moderate | Fever, cough, DM | 5 | Negative | Negative | Negative | |||||||||
| 71 | 72 | M | Severe | SOB, HTN, old TB | 7 | Negative | Negative | Negative | |||||||||
| 72 | 72 | F | Severe | Fever, cough, SOB | 8 | Negative | Negative | Negative | |||||||||
| 73 | 43 | M | Severe | Fever, cough, SOB, body aches | 8 | Negative | Negative | Negative | |||||||||
| 74 | 57 | M | Moderate | SOB, fever, sore throat, cough | 21 | rejected | rejected | rejected | |||||||||
| 75 | 57 | F | Severe | Cough, nasal discharge, HTN, CAD | 8 | Negative | Negative | Negative | |||||||||
| 76 | 60 | F | Severe | SOB, cough, fever, chest pain, abdominal pain, HTN | 9 | Positive | 31 | 30 | ND | Negative | Positive | 30 | 30 | ND | |||
| 77 | 60 | M | Moderate | Backache, DM, CAD, pulmonary HTN, CLD | 2 | Negative | Positive | 34 | 32 | ND | Negative | ||||||
| 78 | 35 | M | Moderate | Fever, cough, SOB | 14 | Negative | Negative | Negative | |||||||||
Ag = antigen; AKI = acute kidney injury; B/L = bilateral; CAD = coronary artery disease; CKD = chronic kidney disease; CLD = chronic liver disease; COPB = chronic obstructive pulmonary disease; DM = diabetes mellitus; F = female; HBs = hepatitis; HTN = hypertension; M = male; MS = mitral stenosis; ND = not detectable; RHD = rheumatic heart disease; SOB = shortness of breath; TB = tuberculosis.
Cyclic threshold value of E gene is mentioned only for those patients whose tear film sample showed positive results for severe acute respiratory syndrome coronavirus 2.
∗
Duration from onset of symptoms until collection of sample.