Table 2.
Patient, tumor, and treatment characteristics by KRAS testing, and odds of receiving testing (N=22,542).
| KRAS Testing | Adjusted OR* (95% CI) | |
|---|---|---|
| N=6,794 | ||
| N (%) | ||
| 0–29 | 77 (42.5) | 4.96 (3.59, 6.84) |
| 30–39 | 329 (47.8) | 5.26 (4.37, 6.34) |
| 40–49 | 996 (40.8) | 3.93 (3.44, 4.49) |
| 50–59 | 1766 (35.5) | 3.2 (2.84, 3.61) |
| 60–69 | 1854 (31.4) | 2.58 (2.31, 2.89) |
| 70–79 | 1196 (26.1) | 1.94 (1.73, 2.18) |
| 80+ | 576 (15.3) | 1.00 [Referent] |
| Female | 2972 (29.4) | 0.99 (0.93, 1.06) |
| Male | 3822 (30.8) | 1.00 [Referent] |
| California | 2473 (29.1) | 1.00 [Referent] |
| Connecticut | 397 (38.7) | 1.64 (1.42, 1.88) |
| Detroit | 417 (33.0) | 1.23 (1.07, 1.40) |
| Georgia | 848 (32.2) | 1.11 (1.00, 1.23) |
| Hawaii | 148 (39.8) | 1.81 (1.43, 2.28) |
| Iowa | 286 (30.5) | 1.15 (0.98, 1.35) |
| Kentucky | 394 (27.0) | 0.90 (0.79, 1.03) |
| Louisiana | 320 (20.0) | 0.59 (0.51, 0.67) |
| New Jersey | 637 (24.2) | 0.84 (0.76, 0.94) |
| New Mexico | 222 (43.2) | 2.17 (1.79, 2.63) |
| Seattle | 527 (45.7) | 2.13 (1.87, 2.43) |
| Utah | 125 (28.8) | 0.91 (0.73, 1.14) |
| White | 5193 (30.2) | 1.00 [Referent] |
| Black | 969 (28.6) | 0.97 (0.88, 1.06) |
| Other | 617 (32.2) | 0.95 (0.85, 1.06) |
| Unknown | 15 (23.4) | 0.59 (0.32, 1.07) |
| 2010 | 1386 (24.6) | 1.00 [Referent] |
| 2011 | 1670 (29.5) | 1.31 (1.20, 1.42) |
| 2012 | 1798 (31.8) | 1.46 (1.34, 1.59) |
| 2013 | 1940 (34.7) | 1.65 (1.52, 1.80) |
| Private/Medicare | 5301 (30.6) | 1.00 [Referent] |
| Medicaid | 1009 (28.6) | 0.82 (0.76, 0.90) |
| Uninsured | 370 (30.1) | 0.79 (0.69, 0.90) |
| Unknown | 114 (24.8) | 0.88 (0.70, 1.11) |
| Married | 3759 (33.4) | 1.00 [Referent] |
| Divorced/separated | 826 (30.8) | 0.87 (0.79, 0.96) |
| Widowed | 654 (20.8) | 0.85 (0.76, 0.94) |
| Single/never married | 1300 (30.2) | 0.79 (0.73, 0.86) |
| Unknown | 255 (21.9) | 0.59 (0.50, 0.68) |
| Metro area | 5983 (30.5) | 1.00 [Referent] |
| Non-metro area/rural | 810 (27.9) | 0.85 (0.77, 0.94) |
| Right side Colon | 2701 (29.6) | 1.00 (0.94, 1.07) |
| Left side Colon | 2849 (31.9) | 1.00 [Referent] |
| Rectum | 1244 (27.8) | 0.86 (0.79, 0.94) |
| Adenocarcinoma | 6150 (30.1) | 1.00 [Referent] |
| Mucinous adenocarcinoma | 644 (30.1) | 0.98 (0.88, 1.09) |
| Well (I) differentiated | 277 (29.9) | 1.00 [Referent] |
| Moderately (II) differentiated | 3817 (31.0) | 0.99 (0.85, 1.15) |
| Poorly (III) differentiated | 1431 (31.6) | 0.99 (0.84, 1.17) |
| Undifferentiated (IV) | 252 (34.4) | 1.06 (0.85, 1.32) |
| Unknown | 1017 (25.1) | 0.83 (0.70, 0.98) |
| ≤ T3 | 3347 (30.7) | 1.00 [Referent] |
| ≥ T4a | 2124 (32.7) | 1.04 (0.97, 1.12) |
| TX (Unknown) | 1323 (25.7) | 0.95 (0.87, 1.05) |
| N0 | 1840 (26.8) | 1.00 [Referent] |
| ≥ N1a | 4404 (33.5) | 1.16 (1.07, 1.24) |
| NX (Unknown) | 550 (21.8) | 0.77 (0.69, 0.87) |
| M1a: Liver or lung only | 2998 (30.7) | 1.00 [Referent] |
| M1a: Bone or brain only | 33 (20.5) | 0.68 (0.45, 1.01) |
| M1a: Other single organ/site | 374 (25.0) | 0.74 (0.65, 0.85) |
| M1b: Multiple organs/sites | 3139 (31.7) | 1.05 (0.98, 1.12) |
| M1NOS | 250 (20.9) | 0.67 (0.57, 0.78) |
| Yes | 5601 (31.3) | 1.08 (1.00, 1.17) |
| No | 1193 (25.8) | 1.00 [Referent] |
| Yes | 4221 (25.8) | 1.05 (0.96, 1.14) |
| No or Unknown | 2573 (32.6) | 1.00 [Referent] |
| Yes or recommended | 814 (26.8) | 0.90 (0.82, 1.00) |
| No/unknown/refused | 5980 (28.7) | 1.00 [Referent] |
*
Odds ratios are adjusted for all variables in table.