Table 4.

Hazard ratios for stage IV patients of colorectal cancer: all patients and those with KRAS testing, 2010–12.

		All Patients	KRAS Tested Patients Only
		(N=16,952)	(N=4,854)
		Adjusted HR* (95% CI)	Adjusted HR* (95% CI)
KRAS Tested:	Normal	1.00 [Referent]	1.00 [Referent]
	Mutated	1.04 (0.97, 1.12)	1.04 (0.96, 1.12)
	No Testing Done	1.31 (1.25, 1.39)	-
Age (y):	0–29	1.00 [Referent]	1.00 [Referent]
	30–39	0.98 (0.77, 1.26)	1.13 (0.77, 1.67)
	40–49	1.01 (0.80, 1.26)	1.10 (0.77, 1.58)
	50–59	1.16 (0.93, 1.45)	1.28 (0.90, 1.83)
	60–69	1.39 (1.11, 1.73)	1.51 (1.06, 2.15)
	70–79	1.83 (1.46, 2.28)	1.80 (1.25, 2.57)
	80+	2.83 (2.26, 3.54)	2.73 (1.89, 3.96)
Race:	White	1.00 [Referent]	1.00 [Referent]
	Black	1.11 (1.06, 1.17)	1.18 (1.06, 1.30)
	Other	0.92 (0.86, 0.99)	0.94 (0.85, 1.03)
Diagnosis Year:	2010	1.00 [Referent]	1.00 [Referent]
	2011	0.99 (0.95, 1.03)	0.95 (0.87, 1.04)
	2012	0.94 (0.89, 0.98)	0.93 (0.84, 1.03)
Insurance:	Private/Medicare	1.00 [Referent]	1.00 [Referent]
	Medicaid	1.24 (1.18, 1.31)	1.19 (1.07, 1.32)
	Uninsured	1.32 (1.21, 1.43)	1.25 (1.06, 1.47)
	Unknown	1.10 (0.97, 1.25)	1.23 (0.92, 1.64)
Marital status:	Married	1.00 [Referent]	1.00 [Referent]
	Divorced/separated	1.10 (1.04, 1.17)	1.11 (0.98, 1.23)
	Widowed	1.19 (1.12, 1.26)	1.27 (1.12, 1.43)
	Single/never married	1.20 (1.14, 1.27)	1.23 (1.12, 1.36)
	Unknown	1.00 (0.92, 1.09)	0.85 (0.69, 1.05)
Subsite:	Right side Colon	1.27 (1.22, 1.32)	1.39 (1.28, 1.51)
	Left side Colon	1.00 [Referent]	1.00 [Referent]
	Rectum	0.90 (0.85, 0.96)	0.90 (0.81, 1.01)
Grade:	Well (I) differentiated	1.00 [Referent]	1.00 [Referent]
	Moderately (II) differentiated	0.97 (0.89, 1.07)	1.05 (0.87, 1.27)
	Poorly (III) differentiated	1.43 (1.30, 1.58)	1.68 (1.38, 2.05)
	Undifferentiated (IV)	1.56 (1.37, 1.78)	1.85 (1.44, 2.39)
	Unknown	1.13 (1.02, 1.24)	1.25 (1.02, 1.53)
T Stage:	≤ T3	1.00 [Referent]	1.00 [Referent]
	≥ T4a	1.26 (1.20, 1.32)	1.23 (1.13, 1.34)
	TX (Unknown)	1.14 (1.07, 1.20)	1.09 (0.97, 1.22)
N Stage:	N0	1.00 [Referent]	1.00 [Referent]
	≥ N1a	1.10 (1.05, 1.15)	1.07 (0.97, 1.17)
	NX (Unknown)	1.17 (1.10, 1.25)	1.15 (1.00, 1.32)
M Stage/	M1a: Liver or lung only	1.00 [Referent]	-
Metastatic Sites:	M1a: Bone or brain only	1.77 (1.45, 2.18)	-
	M1a: Other single organ/site	0.78 (0.72, 0.85)	**1.00 [Referent]
	M1b: Multiple organs/sites	1.37 (1.32, 1.43)	1.42 (1.31, 1.53)
	M1NOS	1.28 (1.18, 1.39)	1.21 (0.98, 1.49)
Surgery:	Yes	0.48 (0.46, 0.51)	0.52 (0.47, 0.58)
	No or Unknown	1.00 [Referent]	1.00 [Referent]
Radiation:	Yes or recommended	0.75 (0.70, 0.80)	NS
	No/unknown/refused	1.00 [Referent]	NS
Sex:	Female	0.91 (0.87, 0.94)	NS
	Male	1.00 [Referent]	NS

^*Hazard ratios determined using manual backward selection to retain only those variables significant at p <0.05, except the following variables which were forced into each model: KRAS results, age, race, diagnosis year, insurance, marital status, T stage, N stage, and M Stage/Metastatic sites.

^**Due to small numbers, metastatic sites were not included in the KRAS tested patients only model; overall M stage was used.