Table 2.

Comparison of steroid concentrations between patients with nonclassic 21-hydroxylase deficiency (N21OHD) and controls

Steroid (nmol/L)	N21OHD (N=32)	Controls (N=54)	Ratio of medians N21OHD/Controls	p
17OHP4	1.1 [0.5–2.7]	1.6 [0.8–4.3]	6.5	<0.0001
16OHP4	2.4 [1.4–4.9]	0.6 [0.4–0.9]	4.1	<0.0001
21dF	1.8 [1.3–5.3]	0 [0–0.3]	N/A	<0.0001
Progesterone	0.8 [0.5–1.4]	0.4 [0.3–0.8]	1.8	0.0018
Cortisol	202.5 [125.9–442.8]	249.1 [208.9–373.7]	0.8	0.197
Cortisone	53.7 [30.5–72.3]	51.5 [40.3–60.8]	1.0	0.855
Corticosterone	1.6 [0.8–3.5]	5.9 [3.5–13.6]	0.3	<0.0001
11dF	0.8 [0.5–1.4]	0.9 [0.4–1.6]	0.8	0.626
DOC	0.3 [0.3–0.4]	0.5 [0.4–0.9]	0.6	0.113
A4	4.3 [2.0–8.1]	3.9 [2.2–8.5]	1.1	0.798
T	1.1 [0.5–2.7]	1.6 [0.8–4.3]	0.7	0.195
11OHA4	9.6 [5.1–25.9]	4.5 [2.9–7.1]	2.1	<0.0001
11KA4	1.1 [0.7–1.7]	0.6 [0.4–0.8]	1.7	0.0001
11OHT	1.0 [0.3–1.7]	0.4 [0.3–0.6]	2.2	0.0019
11KT	1.8 [1.2–3.3]	0.9 [0.6–1.3]	2.0	<0.0001
11KT/T	1.8 [1.2–3.0]	0.6 [0.2–0.9]	3.3	<0.0001
11OHA4/A4	2.6 [2.1–4.6]	1.2 [0.7–2.1]	2.0	<0.0001
A4/T	3.8 [2.8–4.5]	3.5 [2.4–4.2]	1.3	0.274

Data are expressed as median [interquartile range]. 17OHP4, 17α-hydroxyprogesterone; 16OHP4, 16- hydroxyprogesterone; 21dF, 21-deoxycortisol; 11dF, 11-deoxycortisol; DOC, 11-deoxycorticosterone; A4, androstenedione; T, testosterone; 11OHA4, 11β-hydroxyandrostenedione; 11KA4, 11-ketoandrostenedione; 11OHT 11β-hydroxytestosterone; 11KT, 11-ketotestosterone.