Table 3:
Comparison between patients with nonclassic 21-hydroxylase deficiency (N21OHD) and controls of the same sex
| Females | Males | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| N21OHD (n=25) | Controls (n=47) | Ratio* | P | N21OHD (n=7) | Controls (n=7) | Ratio* | P | ||
| Age (years) | 27 [18–34] | 28 [21–36] | 0.696 | 9 [8–13] | 18 [12–52] | 0.036 | |||
| BMI (kg/m2) | 26 [22–32] | 28 [23–33] | 0.224 | 21 [19–26] | 26 [15–31] | 0.62 | |||
| 17OHP4 (nmol/L) | 16.8 [8.1–55.7] | 2.3[1–4] | 7.4 | <0.0001 | 24.9 [13.6–55.7] | 2.8 [2.1–3.8] | 9.0 | 0.0006 | |
| 16OHP4 (nmol/L) | 2.3 [1–7.7] | 0.6 [0.3–0.9] | 4.1 | <0.0001 | 2.8 [1.5–7.7] | 0.6 [0.5–0.9] | 5.0 | 0.002 | |
| 21dF (nmol/L) | 1.8 [1.2–5.1] | 0.0 [0.0–0.0] | N/A | <0.0001 | 1.5 [1.3–5.1] | 0.0 [0.0–0.5] | N/A | 0.0006 | |
| Progesterone (nmol/L) | 0.8 [0.4–1.5] | 0.4 [0.3–0.8] | 1.8 | 0.014 | 1.0 [0.5–1.5] | 0.4 [0.3–0.8] | 2.2 | 0.052 | |
| Cortisol (nmol/L) | 233.4 [128.1–555] | 256.0 [206.6–423.6] | 0.9 | 0.429 | 189.7 [81.4–222.1] | 219.0 [129.4–245.4] | 0.9 | 0.318 | |
| Cortisone (nmol/L) | 57 [31.2–64.2] | 52.5 [44.6–63.7] | 1.1 | 0.823 | 50.4 [23.4–64.2] | 39.4 [20.6–52.9] | 1.3 | 0.710 | |
| Corticosterone (nmol/L) | 2.0 [0.8–1.7] | 5.4 [3.3–15.3] | 0.4 | <0.0001 | 1.4 [0.5–1.7] | 5.0 [3.3–14.7] | 0.3 | 0.0006 | |
| 11dF (nmol/L) | 0.8 [0.5–1.4] | 0.6 [0.4–1.4] | 1.2 | 0.482 | 1.1 [0.6–1.4] | 1.1 [0.6–1.6] | 1.0 | 0.477 | |
| DOC (nmol/L) | 0.3 [0.3–0.4] | 0.4 [0.2–0.7] | 0.8 | 0.322 | 0.3 [0.3–0.4] | 0.6 [0.5–0.8] | 0.5 | 0.001 | |
| A4 (nmol/L) | 4.7 [2.6–3.4] | 4.8 [3.1–7.1] | 1.0 | 0.890 | 1.9 [0.6–3.4] | 2.1 [1.0–2.4] | 0.9 | 0.901 | |
| T (nmol/L) | 1.2 [0.8–11.2] | 1.2 [0.9–2.8] | 1.0 | 0.696 | 0.4 [0.2–11.2] | 9.4 [0.6–16] | 0.04 | 0.137 | |
| 11OHA4 (nmol/L) | 10.1 [5.8–28.4] | 4.4 [2.9–7.3] | 2.3 | <0.0001 | 5.4 [3.1–28.4] | 4.2 [1.6–5.3] | 1.3 | 0.318 | |
| 11KA4 (nmol/L) | 1.3 [0.7–1.4] | 0.6 [0.5–0.8] | 2.1 | 0.0003 | 0.9 [0.4–1.4] | 0.6 [0.3–0.8] | 1.4 | 0.105 | |
| 11OHT (nmol/L) | 1.1 [0.5–0.5] | 0.4 [0.3–0.6] | 2.6 | <0.0001 | 0.3 [0.2–0.5] | 0.3 [0.1–0.4] | 1.1 | 0.685 | |
| 11KT (nmol/L) | 2.4 [1.4–2.3] | 0.8 [0.6–1.3] | 2.9 | <0.0001 | 1.4 [0.9–2.3] | 0.4 [0.3–1.0] | 3.2 | 0.024 | |
Data are expressed as median [interquartile range]. 17OHP4, 17α-hydroxyprogesterone; 16OHP4, 16α-hydroxyprogesterone; 21dF, 21-deoxycortisol; 11dF, 11-deoxycortisol; DOC, 11-deoxycorticosterone; A4, androstenedione; T, testosterone; 11OHA4, 11β-hydroxyandrostenedione; 11KA4, 11-ketoandrostenedione; 11OHT 11β-hydroxytestosterone; 11KT, 11-ketotestosterone; F, females; M, males.
*
Ratio of medians N21OHD/Controls