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. Author manuscript; available in PMC: 2021 Jul 28.
Published in final edited form as: Cell Rep. 2020 Jul 28;32(4):107969. doi: 10.1016/j.celrep.2020.107969

Figure 5. Downregulation of H2Dd through m06 and m152 Affects Host MCMV Control.

Figure 5.

(A) Histogram plots and (B) bar charts of 24 h in vitro infection and flow cytometric evaluation of D8-KODO MEFs with GFP-expressing MCMV lacking the indicated ORFs; representative of two independent infections.

(C) MFI of H2Dd in mice homozygous and heterozygous for the D8 transgene (left), compared with BALB/c (H2d/d) and BALB/c η B6 F1 (H2b/d) mice (right); representative of two independent experiments.

(D and E) Three h (D) or 24 h (E) in vivo cytotoxicity with KODO or D8-KODO heterozygous (D8-Het; H2Dd+/−) donor cells. Composite data from two independent experiments.

(F and G) Δm157 or Δm157/m06/m152 MCMV infection of B6 or Rag1−/−(F) and D8-KODO or ΔLy49-1 D8-KODO (G) mice. (F) and (G) are representative titers from two independent experiments.