Table 3:
Treatment Related Toxicities of Cabozantinib and Gemcitabine (n=11 evaluable patients).
| Adverse Event | Grade 1 (n) | Grade 2 (n) | Grade 3 (n) | Grade 4 (n) |
|---|---|---|---|---|
| Hematologic | ||||
| Anemia | 5 | 3 | - | - |
| Neutropenia | 1 | 1 | 5 | - |
| Thrombocytopenia | 2 | 2 | 2 | - |
| Non-Hematologic | ||||
| Fatigue | 5 | 1 | - | - |
| Flu-like symptoms | - | - | 1 | - |
| Diarrhea | 2 | 1 | - | - |
| Nausea | 6 | - | - | - |
| Mucositis | 1 | - | - | - |
| AST/ALT Elevations | 2 | 3 | 5 | - |
| Hypertension | - | 3 | 1 | - |
| Proteinuria | - | 1 | - | - |
| Alopecia | 2 | - | - | - |
| Myalgia | 1 | 1 | - | - |
Grading of severity of adverse events based on NCI CTCAE v4.0.