Table 1. Similar humanness scores for immunogenic and non-immunogenic therapeutic antibodies.

Antibodies	Type (number)	CDR humanness	CDR rare residues	Framework humanness	Framework rare residues
High immunogenicity	Full human (14)	-82 ± 19	4.0 ± 1.8	-21 ± 14	1.6 ± 1.5
	Humanized (14)	-172 ± 24	12.9 ± 3.1	-32 ± 18	2.1 ± 2.0
Low immunogenicity	Full human (11)	-77 ± 29	4.2 ± 2.1	-25 ± 34	1.5 ± 2.5
	Humanized (13)	-178 ± 38	14.5 ± 4.5	-36 ± 22	2.8 ± 2.0

The humanness score was calculated as a negative number close to zero for human-like sequences and large in magnitude for non-human-like sequences.