Table 2. Ethnic comparisons between different variant categories.
| Variant categories | AA BC cases | EA BC cases | Comparison of AA and EA BC cases | ||
|---|---|---|---|---|---|
| # of cases | Percentage | # of cases | Percentage | p-values* | |
| at least one variant of any category | 31 | 88.6% | 40 | 64.5% | 0.016 |
| at least one pathogenic/likely pathogenic variant | 3 | 8.6% | 4 | 6.5% | 0.700 |
| at least one VUS | 14 | 40.0% | 9 | 14.5% | 0.006 |
| at least one benign/likely benign variant | 25 | 71.4% | 36 | 58.1% | 0.274 |
| multiple variants of any category | 18 | 51.4% | 20 | 32.3% | 0.084 |
| multiple pathogenic/likely pathogenic variants | 0 | 0.0% | 0 | 0.0% | 1 |
| multiple VUS | 1 | 2.9% | 0 | 0.0% | 0.361 |
| multiple benign/likely benign variants | 13 | 37.1% | 12 | 19.4% | 0.089 |
| at least one pathogenic variant and one VUS | 1 | 2.9% | 1 | 1.6% | 1 |
| at least one pathogenic variant and one benign/likely benign variant | 1 | 2.9% | 3 | 4.8% | 1 |
| at least one VUS and one benign/likely benign variant | 9 | 25.7% | 5 | 8.1% | 0.032 |
(AA) African American; (BC) Breast cancer; (EA) European American;
*p-values generated using Fisher’s Exact Test.