Table 3. Results of multivariate analysis for independent predictors of NAFLD having elevation of ALT among Non-MS, Pre-MS, and MS groups.
| Non-MS group | Pre-MS group | MS group | ||||
|---|---|---|---|---|---|---|
| Factor | OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value |
| BMI (kg/m2) | 1.358 (1.232–1.496) | < 0.001 | 1.179 (1.059–1.312) | < 0.005 | ||
| Hypertension | 0.416 (0.937–1.004) | < 0.05 | ||||
| HDL-C (mg/dL) | 0.955 (0.934–0.975) | < 0.001 | 0.963 (0.941–0.987) | < 0.005 | ||
| LDL-C (mg/dL) | 1.012 (1.005–1.020) | < 0.005 | ||||
| HbA1c (%) | 2.473 (1.531–3.995) | < 0.001 | ||||
| IGT | 2.605 (1.469–4.621) | < 0.005 | ||||
| UA (mg/dL) | 1.315 (1.061–1.631) | < 0.05 | ||||
| AST (IU/L) | 1.211 (1.171–1.252) | < 0.001 | 1.310 (1.224–1.402) | < 0.001 | 1.240 (1.178–1.305) | < 0.001 |
| GGT (IU/L) | 1.018 (1.003–1.033) | < 0.05 | 1.021 (1.021–1.033) | < 0.001 | ||
All the parameters that had a P value of less than 0.05 by univariate analysis were assessed using stepwise multivariate logistic regression analysis adjusted age and gender.
ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; CI, confidence interval; GGT, gamma-glutamyl transpeptidase; HbA1c, hemoglobin A1c; HDL-C, high-density lipoprotein cholesterol; IGT, impaired glucose tolerance; LDL-C, low-density lipoprotein cholesterol; MS, metabolic syndrome; NAFLD, nonalcoholic fatty liver disease; OR, odds ratio; UA, uric acid.