Table 3.
Fleas recovered in premises traps in homes when dogs were administered two monthly oral treatments of lotilaner or spinosad.
| Study week | n | Geometric mean | Percent change from Day 0 | Arithmetic mean | Percent change from Day 0 | SD | Minimum | Median | Maximum | p-values* | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Between group | |||||||||||
| 0 | Spinosad | 22 | 22.2 | 0.0 | 46.4 | 0.0 | 107.8 | 5.0 | 23.0 | 524.0 | 0.642 |
| Lotilaner | 22 | 19.2 | 0.0 | 30.8 | 0.0 | 36.4 | 4.0 | 20.0 | 152.0 | ||
| 1 | Spinosad | 22 | 3.6 | 83.7 | 83.0 | −78.8 | 366.2 | 0.0 | 2.0 | 1722.0 | 0.806 |
| Lotilaner | 22 | 4.1 | 78.5 | 7.2 | 76.5 | 8.4 | 0.0 | 4.0 | 26.0 | ||
| 2 | Spinosad | 19 | 3.8 | 82.8 | 64.4 | −38.8 | 259.6 | 0.0 | 2.0 | 1136.0 | 0.895 |
| Lotilaner | 22 | 3.9 | 79.4 | 8.9 | 71.1 | 15.5 | 0.0 | 3.0 | 70.0 | ||
| 3 | Spinosad | 21 | 5.0 | 77.4 | 31.0 | 33.3 | 71.8 | 0.0 | 3.0 | 284.0 | 0.182 |
| Lotilaner | 21 | 2.7 | 85.7 | 4.6 | 85.1 | 4.4 | 0.0 | 4.0 | 13.0 | ||
| 4 | Spinosad | 20 | 1.7 | 92.5 | 10.2 | 78.1 | 33.0 | 0.0 | 0.5 | 148.0 | 0.815 |
| Lotilaner | 20 | 2.1 | 89.0 | 4.1 | 86.8 | 6.2 | 0.0 | 2.0 | 26.0 | ||
| 5 | Spinosad | 19 | 0.5 | 97.6 | 1.9 | 95.9 | 5.5 | 0.0 | 0.0 | 23.0 | 0.368 |
| Lotilaner | 18 | 0.5 | 97.5 | 1.1 | 96.6 | 2.5 | 0.0 | 0.0 | 10.0 | ||
| 6 | Spinosad | 19 | 0.3 | 98.5 | 0.8 | 98.3 | 2.0 | 0.0 | 0.0 | 7.0 | 0.316 |
| Lotilaner | 20 | 0.2 | 98.8 | 0.5 | 98.5 | 1.4 | 0.0 | 0.0 | 6.0 | ||
| 7 | Spinosad | 18 | 0.2 | 99.3 | 0.4 | 99.2 | 1.4 | 0.0 | 0.0 | 6.0 | 0.169 |
| Lotilaner | 20 | 0.1 | 99.7 | 0.1 | 99.7 | 0.5 | 0.0 | 0.0 | 2.0 | ||
| 8 | Spinosad | 18 | 0.1 | 99.7 | 0.1 | 99.8 | 0.5 | 0.0 | 0.0 | 2.0 | 0.257 |
| Lotilaner | 20 | 0.1 | 99.7 | 0.1 | 99.7 | 0.5 | 0.0 | 0.0 | 2.0 | ||
SD Standard deviation.
*
Within group p-values (based on geometric means) comparison to Day 0 generated by the Wilcoxon signed rank test. Week 1 through Week 8, for both groups p < 0.001. Between group p-values generated by repeated measures analysis of variance with Group, Week and Group by Week as fixed effects.