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C-terminal degrons are targeted by a diverse array of E3 ubiquitin ligases, all of which employ tandem repeat domains to facilitate degron recognition. Elongin-B (ELOB) and Elongin-C (ELOC) bridge the interaction between the substrate adaptor and Cul2; DNA damage-binding protein 1 (DDB1) functions similarly in the assembly of Cul4 complexes. The full APPBP2 degron can be defined as Rx[2–4]Gx[0–3], with RxxGx and RxxGxx serving as optimal motifs.
