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. 2020 Jul 14;48(4):1463–1472. doi: 10.1042/BST20190950

Table 1. Binding affinity of various ligands to purified MmpL3.

M. smegmatis MmpL3 (from refs [35] and [37]) Mtb MmpL3 (from ref [36])
Compound KD µM Compound KD mM
AU1235 0.29 AU1235 0.1322
ICA38 0.16 BM212 1.2844
SQ109 1.65 SQ109 1.2122
Rimonabant 29 THPP1 2.6307
SPIRO 0.8 NITD304 0.0825
NITD349 0.05 NITD349 0.0054
North100 0.0361
North114 0.0005