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. 2020 Jul 29;48(4):1765–1780. doi: 10.1042/BST20200243

Figure 6. Structures related to intranuclear proteins and interactions.

Figure 6.

(A) Nuclear β-catenin interactions. Structures represented include: human β-catenin bound to mouse ICAT (PDB 1LUJ), mouse β-catenin bound to phosphorylated mouse LEF1 (PDB 3OUX), human β-catenin bound to Xenopus TCF3 (PDB 1G3J), ternary complex of human β-catenin, human TCF4 and human Bcl9 (PDB 2GL7). (B) Mouse LEF1 high mobility group domain (blue–red N-to-C-terminal) bound to DNA (yellow) (PDB 2LEF). (C) Pygopus–Bcl9 interactions. Structure represented include: Drosophila Pygopus–Legless complex (PDB 3ZPV), human Pygopus1–Bcl9 complex (PDB 2VPB), human Pygopus1–Bcl9 dimer of dimers (PDB 2VPD), human Pygopus1–Bcl9-histone H3 tail ternary complex (PDB 2VPG). (D) TLE1 WD repeat dimer (PDB 1GXR). Legend: blue-white — molecule 1 N-to-C terminal; red-white — molecule 2 N-to-C terminal. (E) TLE1 Q domain tetramer (PDB 4OM2). Each chain coloured from N-to-C terminal in blue/red/yellow/green to white. (F) Assembly of the ChiLS complex in 4:2 stoichiometry based on available structures (PDB 6TYD and PDB 6S9S). (G) Structure of nucleosome-bound human BAF complex (PDB 6LTJ).