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. 2020 Jul 17;48(4):1737–1750. doi: 10.1042/BST20200237

Figure 1. Phylogenetic relationships and structural domain architecture of the human RBR E3 ligases.

Figure 1.

All family members contain a conserved RING1–IBR–RING2 (RBR) core (shaded in grey), and annotated ancillary domains. Domains are approximately to scale and annotated according to Uniprot [5] and Pfam [6] databases (accessed 25/05/2020), and literature search. The autoinhibition status and chain-type specificity of each RBR E3 ligase is summarised in the right-hand panels. Domain acronyms: CPH = domain that is conserved in Cul7, PARC, and HERC2 protein, CUE = Coupling of ubiquitin conjugation to ER degradation, DOC = APC10/DOC, LDD = linear ubiquitin chain determining domain, PUB = PNGase/UBA or UBX-containing proteins, RWD = RING finger and WD-domain-containing-proteins and DEAD-like helicases.