Table 1.
Mean METH PK parameters ± SD after 1 mg/kg SC METH.
| Day 7 (METH naive) | Day 19 (post-METH exposure) | |||
|---|---|---|---|---|
| Sham (n=6) | BDL (n=9) | Sham (n=6) | BDL (n=9) | |
| METH AUC0−∞ (ng min/mL) | 10744 ± 883 | 16965 ± 2831a | 11537 ± 889 | 16918 ± 4372a |
| METH t1/2 (min)b | 58 ± 5c | 94 ± 17a | 75 ± 18 | 87 ± 15 |
| METH Cl (mL/min kg)d | 94 ± 7 | 60 ± 9a | 87 ± 7 | 64 ± 20a |
| METH Vd (mL/kg)d | 7819 ± 798c | 8366 ± 1144 | 9939 ± 2424 | 7881 ± 869a |
| AMP/METH AUC0–300 (%) | 31 ± 4 | 25 ± 5a | 32 ± 4 | 27 ± 4a |
a)
significant difference between bile duct ligation (BDL) and sham groups (p < .05)
b)
t1/2 values reported as harmonic mean ± pseudo-standard deviation (28)
c)
significant differences between day 7 and 19 (p < .05)
d)
estimated values due to sc rather than iv administration