Table 3.
Multiple Linear Regression Models
| Outcome: HFFa | R squared: 0.299 | ||
|---|---|---|---|
| Model Variables | B (Unstandardized) | β (Standardized) | P |
| (Intercept) | -10.979 | 0.262 | |
| Ranked F/B Ratio | 0.179 | 0.306 | 0.006 |
| PNPLA3 rs738409 | 3.173 | 0.204 | 0.082 |
| BMI z-score | 6.842 | 0.184 | 0.087 |
| Caucasian | reference | ||
| African American | -8.330 | -0.243 | 0.048 |
| Hispanic | -2.077 | -0.084 | 0.475 |
| Outcome: HFFa | R squared: 0.292 | ||
| Model Variables | B (Unstandardized) | β (Standardized) | P |
| (Intercept) | 2.143 | 0.842 | |
| Ranked Bacteroidetes | -0.169 | -0.289 | 0.009 |
| PNPLA3 rs738409 | 3.530 | 0.227 | 0.052 |
| BMI z-score | 6.522 | 0.175 | 0.107 |
| Caucasian | reference | ||
| African American | -7.571 | -0.220 | 0.072 |
| Hispanic | -1.919 | -0.078 | 0.511 |
| Outcome: HFFa | R squared: 0.245 | ||
| Model Variables | B (Unstandardized) | β (Standardized) | P |
| (Intercept) | -4.003 | 0.708 | |
| Ranked Prevotella | -0.106 | -0.177 | 0.111 |
| PNPLA3 rs738409 | 4.176 | 0.268 | 0.024 |
| BMI z-score | 7.658 | 0.206 | 0.065 |
| Caucasian | reference | ||
| African American | -7.147 | -0.208 | 0.099 |
| Hispanic | -0.928 | -0.038 | 0.759 |
| Outcome: HFFa | R squared: 0.260 | ||
| Model Variables | B (Unstandardized) | β (Standardized) | P |
| (Intercept) | -9.084 | 0.365 | |
| Ranked Gemmiger | -0.134 | -0.226 | 0.048 |
| PNPLA3 rs738409 | 4.429 | 0.284 | 0.015 |
| BMI z-score | 9.851 | 0.265 | 0.018 |
| Caucasian | reference | ||
| African American | -4.566 | -0.133 | 0.303 |
| Hispanic | -0.224 | -0.009 | 0.941 |
| Outcome: HFFa | R squared: 0.268 | ||
| Model Variables | B (Unstandardized) | β (Standardized) | P |
| (Intercept) | 1.515 | 0.892 | |
| Ranked Oscillospira | -0.142 | -0.239 | 0.032 |
| PNPLA3 rs738409 | 4.440 | 0.285 | 0.015 |
| BMI z-score | 6.050 | 0.163 | 0.148 |
| Caucasian | reference | ||
| African American | -7.085 | -0.206 | 0.097 |
| Hispanic | -2.079 | -0.084 | 0.484 |
The table shows that multiple linear regression with HFF as the outcome was conducted separately for F/B ratio, Bacteroidetes, Prevotella, Gemmiger, and Oscillospira, while also including PNPLA3 genotype, BMI z-score, and race in each model. Statistically significant P values are indicated in bold.
Abbreviations: BMI, body mass index; F/B ratio, Firmicutes to Bacteroidetes ratio; HFF, hepatic fat fraction; PNPLA3, Patatin-like phospholipase 3 gene.
aThe model significantly predicts HFF (P < 0.05).