Table 4.

Deep phenotyping measures of Parkinson’s disease

Domain		Motor			Non-motor			Functional	Social
	Activity	Tremor	Other	Automatic	sleep	Cognition
Measures	•Number of steps	•Portion of day with tremor	•Portion of day with dyskinesias	•Heart rate range	•Duration of sleep	•Variability in activities	•Time in bed	•Time at home
	•Gait speed	•Location, amplitude, and frequency of tremor	•Facial movements	•Heart rate variability	•Number of turns in bed and arousals		•Time in bathroom	•Time at home alone
	•Portion of day sitting, standing, walking, and lying down	•Response to therapy		•Respiratory rate	•Frequency and duration of naps		•Frequency of bathroom use	•Lifespace
					•Presence of REM sleep behavior disorder
“DO”	Smartphone application	✓	✓						✓
	Wearable sensors	✓	✓	✓	✓	✓
	Passive in-home monitor	✓			✓	✓		✓	✓
	Video analytics		✓	✓
	Standard clinical assessment	✓	✓	✓		✓	✓
“SAY”	Standard patient-reported outcomes	✓	✓		✓	✓	✓	✓
	PROP assessment	✓	✓	✓	✓	✓	✓	✓	✓