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. 2020 Aug 24;15:6311–6324. doi: 10.2147/IJN.S257164

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© 2020 Chen et al.

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Confocal microscopy images of HepG2 tumor spheroids co-incubated with NPs-EPI, NPs-EPI/HAase (combined with 0.05, 0.1, 0.5, 1.0 mg/mL HAase, respectively) for 1 hour (A), 4 hours (B), and 8 hours (C). The penetration percentage of NPs-EPI and NPs-EPI/HAase (combined with 0.05, 0.1, 0.5, 1.0 mg/mL HAase, respectively) for 1 hour (D), 4 hours (E), and 8 hours (F) at 100 μm sections. Data represent the mean±SD (n=3). *P<0.05, **P<0.01, ***P<0.001. Scale bar represents 100 μm.