Figure 2.

T-cell costimulation blockade facilitates human DIPG, GBM1, and GBM551 tumor cell engraftment in immunocompetent mice. (a) Representative bioluminescent imagings of immunodeficient and immunocompetent mice inoculated with human DIPG, GBM1, and GBM551 xenografts. (b) Longitudinal bioluminescence intensity of each cell line showed stable xenograft survival in both immunocompetent and immunodeficient mice (n = 5 animals/group). Median with IQR, *p < 0.05 compared with immunocompetent mice, Mann–Whitney U test. (c) Kaplan-Meyer curve analysis of survival for immunodeficient and immunocompetent mice (n = 5 animals/group). Two of the five GBM551 mice in the immunocompetent group were sacrificed at 184 d.