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. 2020 Jun 5;9(1):1776577. doi: 10.1080/2162402X.2020.1776577

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Inflammation infiltration in DIPG, GBM1, and GBM551 tumors in immunocompetent mice. (a) Xenografts in immunocompetent mice engaged an innate and adaptive immune cell surveillance, as revealed by microglia (Iba1), leukocyte (CD45), and T-cell (CD3) infiltration. Immunodeficient mice showed only microglial activation. The scale bar is 50 μm. (b) Quantification of histological assessments for Iba1 immunostaining showed microglial activation in both immunocompetent and immunodeficient mice. Quantification of CD45 (c) and CD3 (d) immunostaining showed leukocyte and T-cell infiltration only in immunocompetent mice. N = 9 slices from three animals/group. Mean ± SD, *p < 0.05, **p < 0.01, n.s. is no significant difference, independent t-test.