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. 2020 Jun 3;9(1):1774281. doi: 10.1080/2162402X.2020.1774281

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Myeloid-specific deletion of PDK1 inhibits tumor growth and metastasis.

(a-b) (a) Tumor volumes at the specified time points. The data represent the mean ± SEM of 9 mice per group. p = .0225. (b) Tumor weight (similar to a) aged at 20 weeks of age. Each symbol represents an individual mouse. (c) Representative H&E staining of lung sections. (d) Quantification of lung tumor metastatic nodules (similar to b). The data represent the mean ± SEM of 8 mice per group. (e) Tumor volumes of subcutaneous B16-GMCSF tumors at the specified time points. Data represent the mean ± SEM of 7 mice per group. Data shown represent at least three independent experiments. *P < .05, **P < .01. The data were analyzed using the Two-way ANOVA (a and e) or Unpaired Student’s t-tests (two-tailed) (b and d).