. 2020 May 14;9(1):1760685. doi: 10.1080/2162402X.2020.1760685

Table 2.

Effects of AXT201 on TIME cell populations.

Category	Cell Type	Parent Population	Populations, Mean (SEM)
Category	Cell Type	Parent Population	Water	n	AXT049	n	p-value
T-Cells	CD4⁺	% Live	2.385 (0.3034)	15	2.403 (0.6656)	14	0.1437^b
	CD8+	% Live	0.6255 (0.07590)	15	0.5135 (0.06845)	14	0.3710^b
	Treg	% Live	0.5260 (0.1065)	10	0.2625 (0.05763)	11	0.0378^b
Isolated CD8⁺ Cells: Secretions	IFNγ	% CD8	9.688 (2.063)	10	16.32 (1.397)	10	0.0149^a
	Granzyme B	% CD8	13.40 (2.059)	10	12.24 (1.180)	9	0.6419^a
	Normalized IL-2	% CD8	100.0 (11.63)	9	117.3 (9.897)	9	0.2743^a
	TNFα	% CD8	10.90 (1.334)	10	11.30 (0.6816)	9	0.7984^a
Isolated CD8⁺ Cells: Surface Markers	Effector	% CD8	77.29 (7.452)	5	88.57 (1.624)	5	0.2222^b
	Exhausted	% CD8	51.74 (9.671)	4	54.55 (5.377)	5	1.0000^b
	CTLA4+	% CD8	27.81 (7.641)	5	21.53 (3.885)	5	0.8413^b
	Activated	% Effector	17.57 (3.451)	5	27.87 (2.814)	5	0.0317^b
Myeloid	CD11b⁺	% Live	50.30 (1.743)	15	43.83 (2.253)	14	0.0301^a
	Macrophages	% CD11b+	36.54 (4.046)	12	35.40 (3.907)	11	0.8294^b
	Macrophages	% Live	11.54 (1.133)	12	9.989 (1.477)	12	0.4136^a
	Arg1+ Macrophages	% Macrophages	63.19 (2.375)	12	59.80 (4.318)	11	0.4896^a
	Normalized M-MDSC	% Live	100.0 (9.208)	15	72.14 (8.782)	15	0.0421^b
	PMN-MDSC	% Live	10.55 (1.226)	15	9.284 (1.074)	14	0.4485^a
Checkpoint	PD-L1⁺	% Live	57.41 (3.114)	15	46.59 (3.069)	14	0.0201^a
	CD11b⁺	% PD-L1+	82.24 (3.312)	15	83.94 (2.990)	14	0.7081^a
	CD11b⁻	% PD-L1⁺	17.76 (3.312)	15	16.06 (2.990)	14	0.7081^a

^aSamples were normally distributed; p-values were determined by Student’s t-test.

^bSamples were not normally distributed; p-values were determined by the Mann-Whitney test

Significant pairs (p < 0.05) are bold and underlined.