Figure 4.

Significantly enriched pathways and immune infiltration alteration with signature 1 activities.

(a) Top enriched pathways in distinct signature 1 activity groups (no vs yes) was assessed by using GSEA. (b) Correlation between signature 1 activities and IPS. Distribution of T cell-inflamed GEP scores (c) and mutant-allele tumor heterogeneity (MATH) score (d) with respect to signature 1 status in TNBC. (e) Tumor infiltrating lymphocytes (TILs) level with signature 1 in TNBC were estimated by CIBERSORT algorithm. All comparison was calculated by Wilcoxon rank-sum test.