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. 2020 Jun 2;9(1):1770565. doi: 10.1080/2162402X.2020.1770565

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Effects of IL-2 and no-alpha mutein on splenic T cells in naïve C57Bl/6. (a–d), absolute numbers of CD8⁺ central memory T cells (TCM) (CD8⁺CD44^high CD62L⁺) (a), CD8⁺ effector memory T cells (TEM) (CD8⁺CD44^highCD62L⁻) (b), CD4⁺ TCM cells (CD4⁺CD44^highCD62L⁺) (c), and CD4⁺ TEM cells (CD4⁺CD44^highCD62L⁻). (d) of spleens from C57Bl/6 mice, injected with PBS, IL-2 or no-alpha mutein at day 0 and day 4, and analyzed by flow cytometry at day 6. (e), No-alpha mutein kept the percentages of FoxP3⁺CD4⁺ T cells to the level of control mice. (f), Mice receiving no-alpha mutein showed lower ratio of FoxP3⁺CD4⁺ T cells/FoxP3⁻ CD4⁺ T cells. Data correspond to three independent pooled experiments; IL2 (n = 13), no-alpha (n = 13), and PBS (n = 10). (a–f), Each symbol represents an individual mouse. Horizontal bars represent the mean ± SEM (*, P <.05; **, P <.01; ***, P <.001; ns, not significant).