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. 2020 Jun 2;9(1):1770565. doi: 10.1080/2162402X.2020.1770565

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Effect of anti-CD20 + no-alpha mutein combination therapy on CD4⁺ T cell subsets. The anti-CD20 + no-alpha mutein combination therapy increased the percentages of Th1/(IFNγ⁺CD4⁺CD3⁺) (a), kept the percentages of Th17/(IL-17A⁺CD4⁺CD3⁺) to the level of anti-CD20 mAb-treated mice (b) and induced a decrease of the percentage of Treg/(FoxP3⁺CD4⁺CD3⁺), (c) of stimulated splenocytes from C57Bl/6 mice injected with EL4-huCD20 cells, evaluated by flow cytometry, at days 14 and 21. Dotted lines represent the mean values obtained with isotype control-treated C57Bl/6 mice for the indicated population. Data correspond to two independent pooled experiments; n = 10. Each symbol represents the relative percentage of the indicated cell subset among the total (Treg+Th1+Th2+Th17) CD4⁺ T-cell compartment for one individual mouse. Horizontal bars represent the mean ± SEM (*, P < .05; **, P < .01; ***, P < .001; ns: not significant).