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. 2020 Jun 2;9(1):1770565. doi: 10.1080/2162402X.2020.1770565

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Anti-CD20 + no-alpha mutein combination therapy activates CD8⁺ T cell subset. Percentage of CD8⁺ T cells expressing IFNγ⁺ (a), perforin⁺ (b), and granzyme B⁺ (c) of spleens from C57Bl/6 mice analyzed by flow cytometry 14 days after challenge with 2 × 10⁵ EL-4-huCD20 cells and treated with the described different treatments. Dotted lines represent the mean values obtained with isotype control-treated C57Bl/6 mice for the indicated population. Data correspond to two independent experiments (n = 4–7 per group). Horizontal bars represent the mean ± SD (Kruskal-Wallis, Dunn’s post hoc test, *, P < .05; **, P < .01; ***, P < .001; ns, not significant).