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. 2020 Jun 2;9(1):1770565. doi: 10.1080/2162402X.2020.1770565

Figure 6.

Figure 6.

Increase in the macrophages number in animals receiving the anti-CD20 + no-alpha mutein combination therapy. (a), Mice treated with anti-CD20 + no-alpha mutein increased the absolute number of MΦ (CD11b+CD11cGr1lo F4/80+) cells. Absolute numbers of spleen MΦ expressing IA/IE class II molecules (b), and FcγRII, FcγRIII (CD16/32) and FcγRIV (c) from C57Bl/6 mice analyzed by flow cytometry 14 days after challenge with 2 × 105 EL-4-huCD20 cells and receiving different treatments. Dotted lines represent the mean values obtained with isotype control-treated C57Bl/6 mice for the indicated population. Data correspond to two independent experiments (n = 5–7 per group). Horizontal bars represent the mean ± SD (Kruskal-Wallis, Dunn’s post hoc test, *, P < .05; ***, P < .001; ns: not significant).