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. 2020 Jun 23;9(1):1782575. doi: 10.1080/2162402X.2020.1782575

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Intracellular monocyte production of inflammatory cytokines before and after RUX therapy. Intracellular production of pro-inflammatory cytokines in total monocytes from PBMC of healthy donors (HD; n = 30) and MF (n = 30) PBMCs (at baseline (MF baseline T0) and after 6 months of RUX therapy (MF RUX (T6 m); n = 20) with or without LPS stimulation (4 hours) is shown. Above, representative histograms identify the IL1β (a), TNF-α (b) and IL6 (c) positive total monocyte of one healthy donors (HD) and one MF patient (at baseline (T0) and after 6 months of RUX therapy (T6 m)) in the presence or absence of LPS stimulation. Unstimulated (blue) and LPS-stimulated (light blue) monocytes are shown superimposed on each other. Below, bars represent the mean percentage of monocytes producing IL1β (A), TNF-α (B) and IL6 (C) ± S.E.M. (Two-way ANOVA test; ***p < .001).