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. 2020 Jun 1;9(1):1762473. doi: 10.1080/2162402X.2020.1762473

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Construction of gene signature.

(a) Heat map showed differentially expressed genes in our microarray data from patients with Gleason scores ≤6 and ≥8. (b) Volcano plot of differentially expressed genes between tissues with Gleason score ≤6 and tissues with Gleason score ≥8 in FUSCC set. The red dot represents up-regulated genes and blue dot represents down-regulated genes. (c) Volcano plot of differentially expressed genes between tissues with Gleason score ≤6 and tissues with Gleason score ≥8 in discovery set. The red dot represents up-regulated genes and blue dot represents down-regulated genes. (d) LASSO coefficient profiles of the 167 candidate genes. A vertical line is drawn at the value chosen by 10-fold cross-validation. (e) Partial likelihood deviance for the LASSO coefficient profiles. Six genes were selected at the value (lambda.min).