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. 2020 May 22;9(1):1761229. doi: 10.1080/2162402X.2020.1761229

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Analyses of grouped cytokine responses to virotherapy and checkpoint inhibitor treatments on day 7.

Expression values from three different patient-derived tumor histocultures were plotted together. (a) Fold change in immunostimulatory cytokines. (b) Fold change in immunosuppressive effectors. (c) Overall suppression (including TGF-b and arginase) vs overall stimulation (including IFNg, IFNb, granzyme B, and CXCL10). (d) Pearson’s r correlation between immunostimulatory cytokine expression and tumor histoculture viability.