Table 1.
Human plasma proteins interacting with VC1 in pulldown assays
The bound material of VC1 pulldown assays from plasma samples was analyzed by LC–MS. Of 295 proteins identified and listed in supporting Dataset S1, 20 were selected using a cut-off of ≥3 positive identifications over 8 pulldown assays.
| String accession | Accession | Description | Gla domain | Molecular mass | Positive identification |
|---|---|---|---|---|---|
| kDa | |||||
| F2 | P00734 | Prothrombin | + | 70 | 8 |
| C4BPA | P04003 | C4b-binding protein α chain | 67 | 8 | |
| PROS1 | P07225 | Vitamin K-dependent protein S | + | 75.1 | 8 |
| C4A | P0C0L4 | Complement C4A | 192.7 | 8 | |
| F9 | P00740 | Coagulation factor IX | + | 51.7 | 6 |
| A2M | P01023 | α2-Macroglobulin | 163.2 | 6 | |
| VTN | P04004 | Vitronectin | 54.3 | 5 | |
| THBS1 | P07996 | Thrombospondin-1 | 129.3 | 5 | |
| ITIH2 | P19823 | Inter-α-trypsin inhibitor heavy chain H2 | 106.4 | 5 | |
| COMP | P49747 | Cartilage oligomeric matrix protein | 82.8 | 5 | |
| IGHG2 | P01859 | Immunoglobulin heavy constant γ2 | 35.9 | 4 | |
| IGHM | P01871 | Immunoglobulin heavy constant μ | 49.4 | 4 | |
| PROZ | P22891-2 | Isoform 2 of vitamin K-dependent protein Z | + | 47 | 4 |
| C3 | P01024 | Complement C3 | 187 | 3 | |
| IGHA1 | P01876 | Immunoglobulin heavy constant α1 | 37.6 | 3 | |
| FGA | P02671-1 | Fibrinogen α chain | 94.9 | 3 | |
| F5 | P12259 | Coagulation factor V | 251.5 | 3 | |
| FRK | P42685 | Tyrosine-protein kinase FRK | 58.2 | 3 | |
| ITIH3 | Q06033-1 | Inter-α-trypsin inhibitor heavy chain H3 | 99.8 | 3 | |
| TTN | Q8WZ42-12 | Isoform 12 of Titin | 3992.1 | 3 |