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. 2020 Jul 7;295(35):12408–12425. doi: 10.1074/jbc.RA120.014125

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© 2020 Lengyel et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 3. — Unique pharmacological profile of the TRESK/TREK-2 tandem channel. The TRESK/TREK-2 tandem channel was expressed in Xenopus oocytes. Currents were measured as described in the legend to Fig. 1. Currents were normalized to the value measured in 80 mm K⁺ before the application of the drug(s). Changes of the extracellular K⁺ concentration and application of the different pharmacological agents are indicated by the horizontal bars above the graph. Data are plotted as mean ± S.D. (error bars). A, oocytes were stimulated with ionomycin (0.5 μm), leading to an activation of the tandem channel (n = 7 oocytes). B, application of A2764 (100 μm) inhibits the current of the tandem channel (n = 6 oocytes). C, TRESK/TREK-2 channels were activated via ionomycin prior to perfusion of A2764 (n = 6 oocytes). D, T2A3 activates the TRESK/TREK-2 tandem channel in a concentration-dependent manner. E and F, TRESK/TREK-2 tandem channels were activated by ionomycin (n = 7 oocytes) and cloxyquin (n = 6 oocytes), respectively. Subsequent application of T2A3 (30 μm) further increased the current.