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Comparison between the UGP-glucuronic binding sites of B. cereus epimerase (left) and A. thaliana UDP-apiose/UDP-xylose synthase (right, PDB entry 6H0N). The two enzymes share the same short-chain alcohol dehydrogenase site and catalytic (Ser/Thr-Tyr-Lys) triad. However, their sugar cavities have different shapes. The more spacious site of the epimerase is instrumental to a swing-rotation conformational change that the sugar undergoes after oxidation by NAD+.
