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. 2020 Jul 20;295(35):12545–12558. doi: 10.1074/jbc.RA120.012792

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© 2020 Ahmad et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 4. — BA effects on additional Mn transporters. A–D, expression of Slc11a2 and Slc39a14 (A), Slc39a8 in organoids (C), and their corresponding human genes in Caco-2 cells (B and D) (n = 4–8 wells of cells or organoids per group). E and F, Slc39a8 expression in organoids exposed to human BA pools with or without LCA (E) and mouse BA pools with or without CDCA (n = 4 wells of organoids/group) (F). G, Slc39a8 expression in organoids generated from Vdr^+/+, Vdr^+/–, and Vdr^–/– littermates after exposure to human BA pools (n = 6 wells of organoids/group). Full result tables for one-way ANOVA (A–D and G) and two-way ANOVA (E and F) and post hoc pairwise comparisons are shown in Table S7. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ns, not significant. Error bars, S.D.