Table 2.
Pathway analysis of 516 genes induced by both human low-12HBA and mouse low-12HBA pools
| GO term | Description | Count | Percentage | p | Genes | List total | Population hits | Population total | -Fold enrichment | False discovery rate |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0006629 | Lipid metabolic process | 39 | 7.88 | 1.60E−11 | HSD17B11, ACOX1, CHKA, PTGS2, ALOXE3, CHKB, EHHADH, ABHD3, ASAH2, APOB, INSIG2, APOBR, ACOT12, ETNK1, MGLL, PLCD1, HSD17B4, PLCB1, ACAA1B, ACSL5, SCD1, SOAT2, MOGAT2, CUBN, NCEH1, LIPA, PLB1, E PHX2, ACACB, LPIN2, LPCAT3, LPCAT4, GDPD2, MTTP, PCX, CLPS, HMGCS2, LIPH, VLDLR | 425 | 459 | 18,082 | 3.61500961 | 2.70E−08 |
| GO:0016491 | Oxidoreductase activity | 40 | 8.08 | 1.57E−08 | HSD17B11, ME1, ACOX1, CYP24A1, ALDH1L1, CYP3A25, PTGS2, ALOXE3, EHHADH, OSGIN1, ALDH1L2, ALDH3A2, MTHFD2, FMO5, ADH1, ALDH1A3, ADH4, GPX3, ALDH1A7, SMOX, HSD17B4, NOS2, QSOX1, CYP3A44, ADH6A, SCD1, SUOX, CYP3A13, CYP3A11, DHRS9, POR, AKR1B8, CYP4A10, DHRS1, AKR1B7, RDH10, HSDL2, TPH1, BCO2, RETSAT | 415 | 604 | 17,446 | 2.78401021 | 2.34E−05 |
| GO:0052689 | Carboxylic ester hydrolase activity | 13 | 2.63 | 4.39E−07 | NCEH1, ACOT2, ABHD3, ACOT1, ACOT5, ACOT4, ACOT3, ACOT12, CES2A, CES1G, MGLL, LIPH, CES2B | 415 | 81 | 17,446 | 6.74692845 | 6.56E−04 |
| GO:0055114 | Oxidation-reduction process | 38 | 7.68 | 1.66E−06 | HSD17B11, ME1, ACOX1, CYP24A1, ALDH1L1, CYP3A25, PTGS2, ALOXE3, EHHADH, ALDH1L2, ALDH3A2, MTHFD2, FMO5, ADH1, ALDH1A3, ADH4, GPX3, ALDH1A7, SMOX, HSD17B4, NOS2, QSOX1, CYP3A44, SCD1, SUOX, CYP3A13, CYP3A11, DHRS9, POR, AKR1B8, DHRS1, CYP4A10, AKR1B7, RDH10, HSDL2, TPH1, BCO2, RETSAT | 425 | 676 | 18,082 | 2.39163244 | 0.00281558 |
| GO:0005102 | Receptor binding | 27 | 5.45 | 6.36E−06 | PVR, ACOX1, FGF15, EHHADH, ACOT2, ACOT4, SCT, ANG, GSTK1, CCDC129, NOS2, HSD17B4, FGF3, MATK, H2-Q2, PLAT, ICOSL, H2-Q1, BTNL2, EPHX2, CD160, PLAUR, LAMA3, GM8909, LAMA5, H2-BL, VEGFA | 415 | 412 | 17,446 | 2.7549538 | 0.00950826 |
| GO:0047617 | Acyl-CoA hydrolase activity | 6 | 1.21 | 8.08E−06 | ACOT12, ACOT2, ACOT1, ACOT5, ACOT4, ACOT3 | 415 | 13 | 17,446 | 19.4024096 | 0.01207519 |
| GO:0006631 | Fatty acid metabolic process | 15 | 3.03 | 1.89E−05 | SCD1, ACOX1, LIPA, PTGS2, ALOXE3, EHHADH, ACACB, LPIN2, CYP4A10, ACOT12, MGLL, FABP2, HSD17B4, ACAA1B, ACSL5 | 425 | 156 | 18,082 | 4.09095023 | 0.03207602 |
| GO:0000038 | Very long–chain fatty acid metabolic process | 6 | 1.21 | 2.44E−05 | ACOX1, ACOT2, HSD17B4, ACOT5, ACOT4, ACOT3 | 425 | 16 | 18,082 | 15.9547059 | 0.04137758 |