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. 2020 Aug 31;10:14331. doi: 10.1038/s41598-020-71229-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Females have higher H2A.Z binding than males in a gene-specific way. ChIP was conducted to assess binding of H2A.Z, normalized for H3 binding at the same loci, at several genes related to neural plasticity. There were no sex differences in H2A.Z binding at Fos, Arc, or Gadd45b, but females had significantly more H2A.Z at B2m, Fkbp5, and Th compared to males. Data are shown as Mean ± SEM, *p ≤ 0.05. N = 8–10/sex.