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. 2020 Aug 31;10:14331. doi: 10.1038/s41598-020-71229-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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H2A.Z has sex-specific effects on fear memory. (a) Control and H2A.Z cKO male and female mice were tested for contextual fear conditioning using a single 0.5 mA foot-shock. Freezing data are shown for (a) the training session and (b) the 24 h recall test. N = 22–25 for males; N = 12–13/females (c) To exclude potential masking effects of tamoxifen on H2A.Z’s function in females, Cre⁺ females were treated with either oil or tamoxifen and memory was tested as in a. N = 6/group (d) A less robust, non aversive form of hippocampus-dependent memory was assessed using the Object in Place (OiP task). Discrimination ratio is shown on the left. Additional analyses of the data show the amount of time spent with objects placed in the familiar vs novel location (right), with only H2A.Z cKO mice showing a significant difference between familiar and novel locations, irrespective of genotype. N = 10–13 for males; 15–20 for females. Data are shown as Mean ± SEM, *p ≤ 0.05.