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. 2020 Aug 31;10:14331. doi: 10.1038/s41598-020-71229-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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H2A.Z has sex-specific effects on pain hypersensitivity. Given the link between PTSD and pain sensitivity, we tested whether SEFL alters pain hypersensitivity in H2A.Z cKO and control mice using von Frey (mechanical) and radiant heat paw withdrawal (thermal) tests. To test the effect of H2A.Z cKO and SEFL on pain sensitization, mice received a single injection of Complete Frund’s Adjuvant (CFA) into one paw as a model of inflammatory pain, which causes hypersensitivity to mechanical and thermal stimuli. Mice are considered to be hypersensitive when paw withdrawal occurs significantly faster after CFA injection compared to pre-CFA baseline (indicated by the dashed line). Data are shown as Mean ± SEM, p ≤ 0.05. N = 7–13/group.