Table 1.
Demographics and disease characteristics of patients with rheumatoid arthritis at baseline.
| MTX plus rhTNFR:Fc52(n = 32) | MTX plus rhTNFR:Fc24(n = 30) | MTX (n = 26) | Pa | MTX plus rhTNFR:Fc(n = 62) | Pb | |
|---|---|---|---|---|---|---|
| Female, n (%) | 28 (87.50) | 22 (73.33) | 22 (84.62) | 0.32 | 50 (80.65) | |
| Age, years | 40.78 (13.35) | 44.67 (11.73) | 43.31 (9.93) | 0.43 | 42.66 (12.64) | |
| Duration of RA, years | 10.73 (9.92) | 7.63 (9.14) | 7.10 (7.66) | 0.22 | 9.23 (9.60) | |
| Duration of morning stiffness, min | 91.29 (92.47) | 111.33 (87.05) | 101.15 (136.55) | 0.38 | 101.15 (89.67) | 0.36 |
| Rest pain VAS | 62.66 (23.83) | 63.83 (16.38) | 49.27 (25.32) | 0.03 | 63.23 (20.41) | 0.02 |
| HAQ | 1.62 (0.76) | 1.52 (0.56) | 1.20 (0.59) | 0.04 | 1.57 (0.66) | 0.01 |
| Physician VAS | 64.19 (15.66) | 65.97 (14.34) | 57.69 (17.68) | 0.18 | 65.07 (14.93) | 0.07 |
| Patient VAS | 64.41 (16.92) | 67.63 (16.53) | 60.38 (18.54) | 0.30 | 65.97 (16.67) | 0.24 |
| Tender joint count (68) | 19.06 (13.30) | 17.67 (10.77) | 13.96 (7.15) | 0.21 | 18.39 (12.07) | 0.08 |
| Swollen joint count (66) | 11.59 (9.10) | 11.60 (6.56) | 10.92 (6.74) | 0.60 | 11.60 (7.91) | 0.41 |
| ESR, mm/h | 51.59 (21.94) | 56.13 (29.20) | 63.00 (35.17) | 0.61 | 53.79 (25.60) | 0.37 |
| CRP, mg/L | 3.16 (2.81) | 3.97 (3.17) | 6.12 (4.15) | 0.20 | 3.55 (2.99) | <0.01 |
| mTSS | 14.76 (19.65) | 10.17 (13.37) | 13.38 (11.00) | 0.36 | 12.68 (17.10) | 0.30 |
| Joint erosion | 6.86 (9.37) | 5.08 (7.40) | 6.52 (5.90) | 0.27 | 6.06 (8.50) | 0.27 |
| Joint space narrowing | 7.90 (10.86) | 5.08 (6.59) | 6.86 (6.38) | 0.64 | 6.62 (9.20) | 0.44 |
| DAS28 | 4.94 (0.82) | 5.15 (0.82) | 4.88 (0.91) | 0.44 | 5.05 (0.82) | 0.40 |
| CDAI | 33.10 (11.61) | 35.56 (11.52) | 29.65 (11.45) | 0.08 | 34.29 (11.53) | 0.04 |
| SDAI | 36.26 (12.49) | 39.40 (12.56) | 35.77 (13.21) | 0.35 | 37.78 (12.52) | 0.57 |
All values are mean (SD) unless otherwise stated. RA, rheumatoid arthritis; VAS, visual analogue score; HAQ, health assessment questionnaire; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; mTSS, van de Heijde modified Total Sharp Score; DAS28, disease activity score 28; CDAI, clinical disease activity index; SDAI, simplified disease activity index. Pa: comparison among three groups; Pb: comparison between rhTNFR:Fc pooled groups and methotrexate group.