Table 2.
Characteristics of patients with germline predisposition mutation.
| Germline predisposition mutation | pa | OR | ||
|---|---|---|---|---|
| Positive (n = 13) (%) | Negative (n = 167) (%) | |||
| Median age | 40 (range, 0–62) | 51 (range, 1–85) | 0.005** | 0.96 (0.93–0.99) |
| Genetics | ||||
| FLT3 ITD | 2 (15.4) | 27 (16.2) | 0.941 | 0.94 (0.14–3.77) |
| Gene fusion | 4 (30.8) | 67 (40.1) | 0.571 | 0.66 (0.14–2.5) |
| No. of somatic mutations | 1–5 | 0–11 | 0.585 | 1.09 (0.79–1.44) |
| Other test results | ||||
| CD34 negative IP | 5 (38.5) | 61 (36.5) | 0.889 | 1.09 (0.32–3.4) |
| Monocytic differentiation | 4 (25.0) | 35 (21.3) | 0.483 | 1.67 (0.35–6.44) |
| WBC count (× 109/L) | 9,910 | 7,690 | 0.585 | 1.00 (1.00–1.00) |
| (1.3–240.5) | (0.4–248.1) | |||
| Treatment related factors | ||||
| First CR | 12 (92.3) | 143 (85.6) | 0.510 | 2.01 (0.37–37.52) |
| Relapse | 5 (31.3) | 54 (32.9) | 0.760 | 1.31 (0.32–4.78) |
| Expire | 4 (25.0) | 74 (45.1) | 0.397 | 0.56 (0.12–2.11) |
| HSCT | 7 (53.8) | 88 (52.7) | 0.936 | 1.05 (0.33–3.38) |
OR odds ratio, ITD internal tandem duplication, No number, IP immunophenotype, CR complete remission, HSCT hematopoietic stem cell transplantation.
aFisher’s exact test was used. **P ≤ 0.01