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. 2020 Aug 31;10:14333. doi: 10.1038/s41598-020-70353-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genetic inactivation of the efferocytosis receptor MerTK impairs efferocytosis programming uniquely in F4/80 macrophages. (a) UMAP plots of resident macrophage clusters at steady state between Mertk^+/+ and Mertk^−/− mice. (b) Violin Plot of Inflammatory Cytokines and MHCII expression at steady state between F4/80⁺ LPMs and MHCII^HI SPMs Clusters. (c) UMAP dimension reduction plot of macrophages in Mertk^−/− mice after co-cultivation of ACs for 2 or 6 h. (d) Fluorescently labeled (green calcein-AM) apoptotic Jurkat cells were injected into the peritoneum of Mertk^+/+ versus Mertk^−/− mice and subsequently peritoneal lavages were collected and stained for F4/80⁺ LPMs. Percent double positive F4/80⁺ calcein-AM⁺ cells as function of total F4/80⁺ cells were enumerated. *p < 0.03. (e) Venn diagram comparing similar and unique differentially expressed genes. (f) Gene Ontology of unique differentially expressed genes in F4/80⁺ LPMs of Mertk^+/+ versus Mertk^−/− mice using gProfiler and GOplot.