Table 3.

Univariate and Multivariate Cox Proportional Hazard Model Evaluating ADV Viremia and Mortality at D +180 and at D +365 Posttransplant^a

	Overall Mortality at D +180				Overall Mortality at D +365
	Univariate Analysis		Multivariate Analysis		Univariate Analysis		Multivariate Analysis
Variable	HR (95% CI)	P Value	HR (95% CI)	P Value	HR (95% CI)	P Value	HR (95% CI)	P Value
Age (years)
Adult (≥18)	ref				ref		ref
Pediatric (<18)	0.89 (0.48– 1.68)	.7289			0.65 (0.38–1.12)	.1178	0.33 (0.18–0.6)	.0003
HLA Match
Matched	ref		ref		ref		ref
Mismatched	1.68 (0.99–2.85)	.0537	1.77 (1.03–3.07)	.0403	1.56 (1.07–2.31)	.0227	1.97 (1.31–2.95)	.001
Acute GVHD
0–1	ref				ref
2–4	1.4 (0.74–2.66)	.2947			1.37 (0.87–2.16)	.1799
ALC +30 (cells/µL)
≥300	ref		ref		ref		ref
<300	5.51 (3.28–9.25)	<.0001	4.29 (2.48–7.42)	<.0001	3.09 (2.03–4.70)	<.0001	2.82 (1.81–4.39)	<.0001
ADV Viremia
No	ref		ref		ref		ref
Yes	3.77 (2.10–6.73)	<.0001	3.63 (1.96–6.60)	<.0001	2.36 (1.45–3.86)	.0006	2.69 (1.63–4.44)	.0001

Abbreviations: ADV, adenovirus; ALC, absolute lymphocyte count; CI, confidence interval; D, day; GVHD, graft-versus-host disease; HLA, human leukocyte antigen; HR, hazard ratio; ref, reference.

^aAdenovirus viremia was entered as a categorical variable. Sex, underlying disease, and cytomegalovirus recipient serology were included in the model and were not significant.