Table 4.
Univariate and Multivariate Cox Proportional Hazard Model Evaluating AAUC and Mortality at D +180 and at D +365 Posttransplanta
| Overall Mortality at D +180 | Overall Mortality at D +365 | |||||||
|---|---|---|---|---|---|---|---|---|
| Univariate Analysis | Multivariate Analysis | Univariate Analysis | Multivariate Analysis | |||||
| Predictors | HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value |
| Age (years) | ||||||||
| Adult (≥18) | ref | ref | ||||||
| Pediatric (<18) | 0.42 (0.12–1.50) | .1812 | 0.30 (0.09–1.02) | .0546 | ||||
| HLA Match | ||||||||
| Matched | ref | ref | ||||||
| Mismatched | 0.96 (.31–3.03) | .9495 | 0.95 (0.34–2.64) | .925 | ||||
| CMV Serology | ||||||||
| R− | ref | ref | ref | ref | ||||
| R+ | 0.32 (0.10–1.08) | .0668 | 0.22 (0.06–0.87) | .0304 | 0.32 (0.11–0.93) | .0363 | 0.23 (0.07–0.76) | .016 |
| Acute GVHD | ||||||||
| 0–1 | ref | ref | ||||||
| 2–4 | 1.46 (0.52–4.13) | .467 | 2.08 (0.84–5.12) | .1128 | ||||
| ALC +30 (cells/µL) | ||||||||
| ≥300 | ref | ref | ||||||
| <300 | 0.25 (0.09–0.69) | .0074 | 3.61 (1.44–9.04) | .0061 | ||||
| AAUC log10 | 2.26 (1.24–5.12) | <.0001 | 2.95 (1.83–4.75) | <.0001 | 3.02 (1.95–4.67) | <.0001 | 3.00 (1.93–4.65) | <.0001 |
Abbreviation: AAUC, time-averaged area under the curve of ADV viremia; ALC, absolute lymphocyte count; CI, confidence interval; CMV, cytomegalovirus; D, day; GVHD, graft-versus-host disease; HLA, human leukocyte antigen; HR, hazard ratio; R, recipient; ref, reference.
aSex and underlying disease were not significant.